Challenge Owner(s) |
National Skin Centre, Khoo Teck Puat Hospital, Institute of Mental Health (IMH), National Healthcare Group (NHG)
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Organiser(s) |
Enterprise Singapore, National Healthcare Group (NHG)
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Industry Type(s) | Healthcare & Biomedical |
Opportunities and Support | EnterpriseSG would provide relevant support to successful solution proposals. |
Application Start Date | 4 January 2023 |
Application End Date | 27 February 2023 |
Website | Click here to learn more |
About Challenge
NHG OIC is a platform that aims to pair clinicians with a diverse range of partners to collaborate and solve unmet healthcare needs.To encourage the sustainability of solutions, it is crucial to co-develop and integrate them into the clinical workflow. Previous runs of NHG OIC have resulted in successful outcomes such as the formation of MedTech startups and innovative solutions, and we hope to support more of such collaborations.
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Challenge Owner(s) | Tan Tock Seng Hospital |
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Industry Types(s) | Healthcare & Biomedical |
[CS1] A Non-invasive Way to Confirm Benignity of Thyroid Nodules in Ultrasonography for the Expeditious Reassurance of Patients and a Reduction in the Referral Rate for Fine Needle Aspiration
What We Are Looking For
Challenge Owner(s) | Tan Tock Seng Hospital |
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Industry Types(s) | Healthcare & Biomedical |
[CS2] A Way to Lower Pill Burden for Patients with Polypharmacy in Order to Reduce Caregiving Burden and Improve Adherence to Reduce Hospitalizations and Healthcare Costs
• There are limitation of traditional mass-made medicines as discrete strengths and dosageforms is finite and leads to burden of care. This is amplified in Singapore due to our small market
• Up to 70% of patients do not gain efficacy directly from medications dispensed and have tomake modifications to them in one way or another or simply do not take them.
• Multiple medications are needed to treat common conditions such as myocardial infarction,tuberculosis or H. pylori infections.
• Up to 14.5% of Singapore elderly are taking >=5 medications5.
• Up to 60% of patients in Singapore are non-adherent to their medications and this risk isfurther increase 1.45 times if they are taking >=5 medications (polypharmacy).
What We Are Looking For
• The proposed solution should enable patients and caregiver to better manage their medication use due to the limited dosage forms in the market.
• The immediate benefits should translate to better patient experience and adherence and lower care burden.
• Long term benefits will include improve disease management and reduce healthcare costs.
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Challenge Owner(s) | Tan Tock Seng Hospital |
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Industry Types(s) | Healthcare & Biomedical |
[CS3] A Better Way to Train Healthcare Workers to Perform Diabetic Foot Screening to Reduce Man Hours Needed for Diabetic Foot Screening Training
What is Diabetic Foot Screening (DFS) and why do need to transform DFS?
A structured foot check for diabetic foot complications such as neurological, vascular, dermatological changes of his/her feet in a person with diabetes. With the projected rise of diabetes to ~1 million by 2050, there is a need to improve the efficiency of Diabetic Foot Screening (DFS) training.
DFS training is resource taxing, dependent on a small work force and clinic availability.
What We Are Looking ForWe are looking for a virtual reality DFS skill training module for trainees to self-learn before clinical attachment and workplace assessment. Ultimately, the solution should aim to reduce man hours needed for DFS training.
Learn MoreChallenge Owner(s) | Tan Tock Seng Hospital |
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Industry Types(s) | Healthcare & Biomedical |
[CS4] Using Real-time Tactile Biofeedback Wearable Sensors on Sensory Impaired Stroke Patients in Improving Upper Limb Function During Rehabilitation
• Sensorimotor impairment of upper limb(UL) are common after stroke, leading to
difficulty in activities of daily living
• Up to 85% of person with stroke has sensory impairment
• They may experience negative symptoms like numbness, or absence of sensation
over affected area, inability to discriminate position of the limb in space, or
recognize a held object by touch
• Or positive symptoms like tingling paresthesia or pins and needles sensation
which can disturb their daily life
What We Are Looking For
• Task-specific training including intermittent feedback is beneficial for improving motor
function after stroke. Feedback can be in the form of vibration, tactile, pressure, thermal etc (tactile with pressure that provide different intensity preferred), mainly for training use, and could be useful for functional use at home as well
• A solution using combination of passive and active sensory training using instant biofeedback wearable sensor during upper limb sensory re-training for post stroke survivors could potentially improve the motor power, overall functional status and QoL
• A qualitative outcome measures and quantitative feedback can be obtained from both
patients and clinicians during and post rehabilitation in subacute and chronic stroke survivors who suffered from sensory impairment
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Challenge Owner(s) | Tan Tock Seng Hospital |
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Industry Types(s) | Healthcare & Biomedical |
[CS5] Enabling Restricted Weight Bearing Exercise on Post orthopedic trauma patients to improve physical performance and early functional return
• The incidence of tibia fracture is 13 in 100,000 with male-to-female ratio of 3:1 locally.
• According to the AO Principles of Fracture Management, postoperative management of (peri)- or intra-articular fractures of the lower extremities consists of non-weight bearing for 6–12 weeks, followed by partial weight bearing with a 25% increase in weight loading every week
• Premature weight bearing increases stress on implant constructs, risk of fixation failure, loss of reduction and the need of revision surgery
• As such, weight bearing rehabilitation is often cautious, with fear for secondary dislocation of the fracture or failure of mechanical construct
• Furthermore, patients’ compliance with non weight bearing or partial weight bearing regime has been found to be poor. Studies showed that patients actually exceeded the prescribed amount of partial weight bearing
What We Are Looking For
• Patients who suffered from orthopedic injuries over lower limb (e.g. distal femur, or tibial fracture) requiring restricted weight bearing for a period of duration (6-12 weeks) will benefit from early rehabilitation using proposed solution to reduce risk of deconditioning.
• A robotic device or equipment that allow early physical exercises and joint movement with capability of controlled weight bearing to injured limb, should enable early rehabilitation in this population with aim of improvement in muscle strength, physical activity and early return to function in long term
• A feasibility study should be done to assess device’s safety follow by cost and clinical effectiveness evaluation
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Challenge Owner(s) | Tan Tock Seng Hospital |
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Industry Types(s) | Healthcare & Biomedical |
[CS6] Mitigating sedentary behaviour among hospitalized elderly and patients with disability to shorten sedentary period and increase physical activities.
• During hospitalization, patients were spending more time engaged in sedentary behaviour (SB) and were less physically active than after discharge at home.
• This is even more prominent in stroke patients and older adults who spent up to 76% and 96% daily with sitting or lying down.
• Sedentary behaviour has been associated with poor health outcome such as physical and cognitive declined, reduced quality of life, depression and frailty, risk of premature death, mortality, length of hospital stay, and hospital readmission rate.
• Illustrate current state/ practice.
• Early referral to physiotherapist and nursing intervention has been attempted to mitigate the SB, however they were unable to reduce the high prevalence of SB in the hospital significantly due to manpower and resources constraint.
What We Are Looking For
• Early rehabilitation for elderly and patient with disability is beneficial for recovery and favourable outcome:
- Clinically, likely more than 50% in rehab ward (patients with good cognition) will benefit from the proposed solution. (Purely advising patient to increase PA may not address SB based on studies)
- Activities that interrupt period of SB could include sit-to-stand, walking to lounge room to socialise with other patients and walking to restroom rather than using a commode.
• Understanding the perspectives of stakeholders and end-users regarding interventions on ubiquitous health issues is critical to reducing SB among hospitalised older people successfully.
• We propose using sensors or gamification device could potentially interrupt SB among hospitalized patient. This can be in inpatient wards in acute hospitals, subacute rehab wards, community hospitals and/or nursing homes.
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Challenge Owner(s) | Tan Tock Seng Hospital |
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Industry Types(s) | Healthcare & Biomedical |
[CS7] An Augmented Reality Solution to Provide Patient Specific Surgical Visualisation for Patients, Students and Surgeons to Achieve Better Understanding and Safer Surgery
• Surgical planning is often taught utilising 2D pictures, X rays, CT images
• The surgeon then integrates these images into his/her head, coming up with a 3D image for planning of surgical steps
• Surgical models and pictures from educational sources are generic and not patient specific (Not relevant to the current case)
What We Are Looking For
• Target population:
- Patients, Students, Residents, Surgeons - Patients: Better understanding, satisfaction, expectations
- Students: Better understanding
- Residents: Able to visualize better before practice
- Surgeons: Better planning and execution
• Creation of an augmented reality (AR) program that may overlay anatomy onto a patient specific 3D printed model with tracking features and dynamic adaptation to enhance surgical planning. The AR program should ideally be accurate and implementable for clinical usage.
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Challenge Owner(s) | Tan Tock Seng Hospital |
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Industry Types(s) | Healthcare & Biomedical |
[CS8] A Way to Achieve Haemostasis and Clean Operative Field During Laparoscopic Procedures in order to Relieve Stress of Surgeons and Achieve Good Surgical Outcomes
Background of laparoscopic procedures Nearly 15 million laparoscopic procedures were performed every year globally and the US alone contributed 32% of the volume and increasing yearly. The overall laparoscopy and endoscopy devices market was worth 18.39 billion and is growing with compound annual growth rate (CAGR) of 4.8% in the forecast period, 2018-2025 according to the research and markets report published in September 2018.
What We Are Looking For
Company that can develop and the all in one multipurpose haemostatic sponge system for minimally invasive surgeries. The sponge system should ideally clean the operative field, slow/stop bleeding and be readily removed after the procedure.
Possible parameters to measure outcomes:
1. Ease of sponge removal (e.g. without incisions, without specialised instrument)
2. Haemostatic ability of new sponge system
3. Integration new sponge system to surgical protocols
4. Qualitative survey from surgeons on new sponge system vs. old sponge system
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Challenge Owner(s) | Tan Tock Seng Hospital |
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Industry Types(s) | Healthcare & Biomedical |
[CS9] A Way to Monitor the Compliance and Technique of Using Incentive Spirometer for Patients Undergoing Major Abdominal or Thoracic Surgery in Order to Prevent Post-surgery Atelectasis & Pneumonia
• Pulmonary complications can occur in up to 80% of patients after surgery- this is due to general anaesthesia and post-operative pain impairing the ability to take deep breaths.
• Atelectasis is the collapse of one or more parts of the lung
• Most common postoperative pulmonary complication following thoracic or abdominal surgery
• Manifest as fever or hypoxemia and dyspnoea
• Ambulation and performing deep breathing exercises is the best way to reduce the risk of atelectasis
• Patients should use an incentive spirometry after surgery, and sometimes before surgery as well.
What We Are Looking For
• The proposed solution seeks to allow healthcare providers to monitor the technique and compliance of patients performing incentive spirometry
• Patients undergoing major abdominal or thoracic surgery will benefit from this solution
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Challenge Owner(s) | Tan Tock Seng Hospital |
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Industry Types(s) | Healthcare & Biomedical |
[CS10] A way to Optimise the Quality Assurance in CSSD for the Sterilisation of Reusable Medical Devices in order to Reduce the Incidence of Rejected Loads
• All the re-useable medical devices (RMD) for TTSH are reprocessed at Central Sterile Sterilisation Department (CSSD) and these include all the RMD for Operating Theatres, Dental clinic, Inpatient ward, Outpatient, Ambulatory, NCID and many more.
• The RMD includes variety of sets and loose instrument that comes in different sizes and quantities.
• RMD need to be received, sorted, and manual washed prior to loading into washer disinfector, visually inspected for cleanliness and functionality before packing, sterilisaton, quality check before storage or distribution to users.
•All these are performed by staff that are subjected to inconsistent practices and human error.
What We Are Looking For
• Consistent quality assurance of the products produced by CSSD with automation.
• Re- design jobs to raise productivity and job longevity.
• Increase productive with limited manpower.
How will benefit be measured?
• Reduce rejection rate from 1% to zero by user.
• Reduce time taken to reprocess the reusable medical devices reprocessed.
• Increase in numbers of loads performed by the steam sterilisers.
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Challenge Owner(s) | Tan Tock Seng Hospital |
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Industry Types(s) | Healthcare & Biomedical |
[CS11] A Way to Address Monitoring of Treatment Adherence for People with Tuberculosis in order to Achieve Treatment Completion while Reducing the need for in Person DOT Services
• In Singapore, the incidence rate of tuberculosis among Singapore residents has been about 30 – 40 per 100,000. In 2021, incidence rate among Singapore residents was 32.8 per 100,000.
• Mycobacterium tuberculosis spreads via airborne transmission. The treatment of tuberculosis is of public health concern. Traditionally, this consists of 6 months of TB treatment. Failure to complete treatment may result in further transmission, relapse and/or emergence of drug resistant strains.
• Direct observed therapy (DOT) has been the mainstay of treatment monitoring. This involves patients going to the polyclinic daily to be observed to be taking the pills.
What We Are Looking For
• Proposed solution should result in convenience for both patients and healthcare system to monitor and verify treatment adherence. ADOT is a promising approach if patient compliancy can remain high.
• Benefits measurements (polyclinics can be engaged as controls)
• Qualitative – patient feedback on convenience of new treatment monitoring modality versus that of DOT
• Quantitative – treatment completion rate of patients (approximately 90%) on new treatment monitoring modality, healthcare resources saved from reduced need for DOT services.
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Challenge Owner(s) | Tan Tock Seng Hospital |
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Industry Types(s) | Healthcare & Biomedical |
[CS12] The Project Aims to Reduce the Manpower Hours Required to Report LDCT for Lung Cancer Screening, while Maintaining Accuracy. This Would Help to Extend LDCT Screening of Lung Cancer in the Never-smokers
• Globally, lung cancer is the leading cause of cancer-related death, especially among men. Compared with Western countries, Asia-Pacific countries, particularly Singapore, are showing alarming disparities in lung cancer patterns. Data from 2011 shows that 47.7% of lung cancers in Singapore are detected among never-smokers, compared to 10%–15% in Western countries.
• Singapore does not currently have any lung cancer screening programmes in place at the moment. Current recommendations suggest that high-risk individuals undergo targeted screening using low-dose CT thorax (LDCT) who have these factors:
- Adults aged 55-80 years
- 30 pack-year smoking history (For example: a pack a day for 30 years, 2 packs a day for 15 years) • Current smokers
- Smokers who quit within the past 15 years
- Detection of lung cancer on LDCT is a labour intensive and tedious task, as it requires detection of small nodules in a large set of images. In a frequently used dataset (a subset of the lung cancer screening program from 1996 to 1999 in Nagano), the original manual misdetection rate was 76% (38 of 50 nodules were missed).
What We Are Looking For
• Based on the results of the National Lung Screening Trial (NLST), over the course of about seven years, there are approximately three fewer deaths per 1,000 people screened with LDCT than with chest X-ray (17.6 versus 20.7 respectively).
• The NLST showed that lung cancer screening could be cost-effective; it is estimated that screening can save about USD 81,000 per quality-adjusted life-year (QALY) gained over non-screening.
• There are currently a number of solutions available on the market for the automated detection of nodules. The use of these solutions has been shown to improve lung cancer detection sensitivity and false positive rates.
• The hypothesis of the project is that a commercially available AI solution for pulmonary detection and characterisation on LDCT will reduce the manpower hours for interpretation by 20% without significant (<10%) loss of accuracy.
• During the Lung Nodule Analysis 2016 (LUNA16) challenge, the best AI solution reached a sensitivity of 97.2% at the expense of 1 false positive per scan on average.
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Challenge Owner(s) | Tan Tock Seng Hospital |
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Industry Types(s) | Healthcare & Biomedical |
[CS13] A way to Increase the Precision of Retractor Placement for Patients Undergoing Spinal Decompression Surgery in order to Achieve Shorter OT Duration and Reduction in Surgeons’ Exposure to X-ray
• During spine surgery, robotic arm holds key surgical instrumentation in place for the surgeon. The robotic guidance helps surgeon execute the custom surgical plan with precision through micro incision.
• During a spinal decompression procedure, a special retractor system (Metrx tubes see photo in next slide, blue arrow) is used to help the surgeon gain access to the intended surgical site.
What We Are Looking For
• We want to use the robot to target and guide us to this area, and also create a attachment to fix the retractor (orange arrow)
- Prevalence about 50-100 cases per year, and this will help reduce surgical time (by 20%) and xrays (20%).
• Target population
- Surgeons who perform spinal decompression procedure
• Stakeholders involvement
- Patients: Decreased OT time from X hours to Y hours
- Surgeons: Decreased exposure to fluoroscopy from 30 minutes to 20 minutes
- Payors: More cost-effective treatment from shorter hospitalization, and patients do not need to pay for extra set of screw for failed procedures
- Device makers: the new attachment to be compatible with most robot arms, and attachment could be a new consumable for the robots
Outcome parameters pre and post intervention:
• Reduction in OT time by 20% and Radiation to OT staff
• Number of x-ray scans
• Comparison of surgical cost
• Qualitative feedback from surgeons on the new surgical procedure
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Challenge Owner(s) | National Healthcare Group (NHG) |
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Industry Types(s) | Healthcare & Biomedical |
[CS14] An Electronic Portal to Improve Experience of Patients with musculoskeletal Pain When Inputting Outcome Measures, Undergoing Patient Education and Evaluating Physiotherapy Services
• Musculoskeletal pain affects everyone
• It is estimated that up to 80% of individuals would experience an episode of low backpain at some point throughout lifetime
• Currently, MOH has implemented One Rehab framework throughout all public healthcare institutions; This requires all PHIs to use and track similar outcome measures (EQ5D (generic quality of life measure) and PSFS (patient specific functional scale).
• The outcome measures would track improvements in patient’s quality of life and functional abilities
• Education on patient’s condition is done via face to face communication and is not standardized.
• Evaluation of physiotherapy service is not done regularly and patient’s experience measures are not captured
What We Are Looking For
- Better patient experience in filling outcome measures
- Improved accuracy of data
- Portability of data to EPIC system so therapy assistant’s time can be saved for doing other clinical work
- Improved health literacy of patients regarding their own conditions - Capturing of patient’s feedback and evaluation of physiotherapy service
• Benefit can be measured:
- in terms of time saved by therapy assistants and therapists when administering those questionnaires
- accuracy of data
- amount of time patient contact time spent by therapy assistants
- patient’s health literacy/ understanding of their condition
- patient’s experience in doing the modified questionnaires and overall experience of physiotherapy service
- Data of patient’s experiential outcomes can be captured
• We propose creating a one-stop robotic portal for multiple purposes, such as capturing rehab outcomes, deliver educational videos and capture patient’s feedback.
Learn MoreChallenge Owner(s) | Institute of Mental Health (IMH) |
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Industry Types(s) | Healthcare & Biomedical |
[CS15] A Way to Increase the Effectiveness of Transcranial Magnetic Stimulation for Patients with Major Depressive Disorder in order to Achieve Shorter Treatment Duration, Higher Response Rates and Higher Quality of Life
• Major depressive disorder is a prevalent1 (approximately 1 in 20 in Singapore) and disabling2,3 psychiatric condition with a significant treatment resistant (TRD) subpopulation.
• The economic burden of depression in the Asia Pacific region and Singapore5 is high and up to 50% of indirect costs were associated with lost productivity and unemployment.
•The mean annual cost of treatment for depression in Singapore is USD 7,638.6 The current standard of care for depression remains suboptimal with a large proportion of patients not responding satisfactorily and are classified as treatment-resistant depression (TRD). 7
• Current treatment for TRD is either more medication treatment or neurostimulation (transcranial magnetic stimulation/TMS or electroconvulsive therapy/ECT)
What We Are Looking For
• For interest, a precision medicine treatment for depression consist of:
1. A system to ingest fMRI (to map individual brain functional connectomics)
2. Advanced computational analytics on fMRI
3. Output the algorithm to precision robot arm to target iTBS treatment
• Target population
- Patients with treatment resistant depression (failing 1-2 rounds of pharmacotherapy for depression)
• Stakeholders involvement
- Patients: Decreased illness time from 6 weeks to 1 week
- Treatment Facility: Decreased hospitalization time from 6 weeks to 1 week
- Payor: More cost-effective treatment from shorter hospitalization and cheaper treatment (TMS is approved as cost effective treatment by MOH ACE in Jan 2022)
• Outcome parameters pre and post intervention:
- Response rate defined by ≥50% improvement of the depression rating score (MADRS) - Cost effectiveness and Subjective quality of life assessed via self-reported EQ-5D
- Patients’ functioning will be assessed by the self-rated Sheehan Disability Scale (SDS) - Patients’ global cognitive functioning assessed by the Montreal Cognitive Assessment (MoCA)
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Challenge Owner(s) | Khoo Teck Puat Hospital |
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Industry Types(s) | Healthcare & Biomedical |
[CS16] A way to complement existing basic vestibular training for junior PTs in order to improve training efficiency and PTs’ confidence in vestibular-related on-call duties
Dizziness
• Dizziness affect 15% to 20% of adults yearly
• Of these, about 25 percent are related to vestibular disorders (Neuhauser, 2016)
Dizziness and vestibular physiotherapy
• Patients with dizziness are often referred for vestibular physiotherapy assessment
• Vestibular rehabilitation therapy is an advanced area of practice in physiotherapy
• Junior physiotherapists (PTs) need to be trained to manage patients with dizziness
What We Are Looking For
• Improvement in Junior PTs’ exposure and confidence in vestibular rehabilitation
• All Junior PTs to be competent in the skills taught during the basic vestibular training without extension required
• To have an adequate pool of vestibular-trained PTs for on-call duties
• A solution to improve the efficiency of basic vestibular training, by complementing the existing training program.
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Challenge Owner(s) | National Skin Centre |
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Industry Types(s) | Healthcare & Biomedical |
[CS17] A way to improve sun protection practices for patients who has been diagnosed with at least 1 skin cancer in order to achieve secondary prevention of skin cancer
• Skin cancer is the 6th most common cancer in males, and 7th most common cancer in females in Singapore.
• The most common cause is that of prolonged, cumulative ultraviolet ray (UVR) exposure. In order to prevent skin cancer development, one should seek shade or use devices to protect against sun. This include sunblock creams, and UVR-blocking clothes or umbrella.
• Sun protection is essential even on cloudy days or when indoors as the UVR could penetrate the clouds and/or glass.
• The ultraviolet index (UVI) is an international standard index that describes the level of solar UVR on the earth’s surface. The index ranges from 0 to >11. A higher index value indicates a greater potential for harmful effects to the skin and the eyes.
What We Are Looking For
• We propose to develop a portable device that could accurately measure the UVR index at a specific location. In addition, the device would be able to assess if adequate sun protection is employed.
• In general, anyone would be able to benefit from this device. For a start, the target population would be patients who have had 1 or more skin cancers diagnosed as this group of patients would be at risk of developing new skin cancers.
• Benefits can be measured as follows:
- Improvement in the use of sun protection e.g. increase frequency of use of sun protection devices
- Increase awareness in sun protection amongst our patients e.g. survey before and after use of device
- Reduction in skin cancer
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Challenge Owner(s) | Institute of Mental Health (IMH) |
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Industry Types(s) | Healthcare & Biomedical |
[CS18] A way to Reduce Alcohol Intoxication for Patients with Alcohol Use Disorder in order to Reduce the Rate of Presentations to the Emergency Services while Intoxicated
Alcohol Use Disorder
Based on the Singapore Mental Health Study, a national wide, cross sectional epidemiological survey initiated in 2016, lifetime prevalence of alcohol abuse is 4.1% compared to Singapore Mental Health Study done in 2010 of 3.1%
Frequent alcohol use is also associated with increase medical problems, such as liver cirrhosis, alcoholic encephalopathy, frequent falls, and increased risk of suicidality.
Alcoholics that become drunk also often come to the emergency services disinhibited and in various kinds crisis– be it aggression or suicidality only to demand discharge from Emergency Services when sober. This takes up a lot of resources in the acute emergency settings, which results in longer waiting time at the emergency services, and wasting of resources.
What We Are Looking For
Who will mainly benefit
- Healthier community: People with alcohol use disorders who have difficulties abstaining from alcohol
- Hospital processes: Efficient use of manpower and resources with lesser time spent on intoxicated patients in the Emergency Services.
What should the proposed solution seek to achieve?
Reduction in intoxication rates, assessed by number of Emergency Service visits due to intoxication
How will benefit be measured?
Benefit will be measured based on a reduction in frequency of Emergency Room presentations as a result of alcohol intoxication. This will be a proxy to assess for a reduction in the number of alcohol intoxication episodes for patients with alcohol use disorders
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The meet-up session with clinicians would be opened from 16 Jan – 27 Feb 2023 to share and discuss more about the clinical needs. Kindly note that companies can only meet clinicians of their selected clinical needs.
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